Semax
ACTH(4-10) analogue · Met-Glu-His-Phe-Pro-Gly-Pro
Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) analogous to the ACTH(4-10) fragment. It is studied in vitro and in preclinical models for modulation of the BDNF/TrkB neurotrophic system and neuroprotective mechanisms. Reagent intended exclusively for laboratory research — not intended for human consumption.
Key facts
- Class
- Heptapeptide (7 aa)
- Origin
- ACTH(4-10) analogue
- Form
- Lyophilised (powder)
- Status
- Research Use Only
Documented research areas
Study library
All results on PubMedSemax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice.
Liu R, et al. · British journal of pharmacology · 2025
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.
Rahman OF, et al. · Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026
Functional Connectomic Approach to Studying Selank and Semax Effects.
Panikratova YR, et al. · Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2020
The Effect of Peptide Semax, an ACTH(4-10) Analogue, on Intracellular Calcium Dynamics in Rat Brain Neurons.
Kolbaev SN, et al. · Bulletin of experimental biology and medicine · 2025
The Potential of the Peptide Drug Semax and Its Derivative for Correcting Pathological Impairments in the Animal Model of Alzheimer's Disease.
Radchenko AI, et al. · Acta naturae · 2025
Semax, a Copper Chelator Peptide, Decreases the Cu(II)-Catalyzed ROS Production and Cytotoxicity of aβ by Metal Ion Stripping and Redox Silencing.
Tomasello MF, et al. · Bioinorganic chemistry and applications · 2025
Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models.
Sciacca MFM, et al. · ACS chemical neuroscience · 2022
Therapeutic peptides in gerontology: mechanisms and applications for healthy aging.
Mavrych V, et al. · Frontiers in aging · 2026
[The Peptide Drug ACTH(4-7)PGP (Semax) Suppresses mRNA Transcripts Encoding Proinflammatory Mediators Induced by Reversible Ischemia of the Rat Brain].
Dergunova LV, et al. · Molekuliarnaia biologiia · 2021
The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis.
Medvedeva EV, et al. · BMC genomics · 2014
Brain Protein Expression Profile Confirms the Protective Effect of the ACTH((4-7))PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia-Reperfusion.
Sudarkina OY, et al. · International journal of molecular sciences · 2021
Novel Insights into the Protective Properties of ACTH((4-7))PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia-Reperfusion in Rats.
Filippenkov IB, et al. · Genes · 2020
Results retrieved live from PubMed (NCBI). Research literature only — no medical advice.
Research peptides — Research Use Only
- Not for human consumption
- Not for the diagnosis, treatment or prevention of any disease