GHK-Cu
Copper tripeptide-1 · GHK-Copper
GHK-Cu is a complex of the tripeptide Glycyl-L-Histidyl-L-Lysine with a copper ion. It is studied in vitro in research contexts on the extracellular matrix and collagen expression. Research reagent only — not for human or cosmetic use.

Key facts
- Class
- Copper tripeptide (Gly-His-Lys)
- Ion
- Copper (Cu²⁺)
- Form
- Lyophilised (powder)
- Status
- Research Use Only
Documented research areas
Study library
All results on PubMedRegenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data.
Pickart L, et al. · International journal of molecular sciences · 2018
The potential of GHK as an anti-aging peptide.
Dou Y, et al. · Aging pathobiology and therapeutics · 2020
Topically applied GHK as an anti-wrinkle peptide: Advantages, problems and prospective.
Mortazavi SM, et al. · BioImpacts : BI · 2025
GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration.
Pickart L, et al. · BioMed research international · 2015
Exploring the beneficial effects of GHK-Cu on an experimental model of colitis and the underlying mechanisms.
Mao S, et al. · Frontiers in pharmacology · 2025
Are We Ready to Measure Skin Permeation of Modern Antiaging GHK-Cu Tripeptide Encapsulated in Liposomes?
Ogórek K, et al. · Molecules (Basel, Switzerland) · 2025
Phenothiazine-Based Cu(II)-Selective Fluorescent Sensor: GHK-Cu Sensing Applications.
Sahu R, et al. · The Journal of organic chemistry · 2023
Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians.
Mayfield CK, et al. · The American journal of sports medicine · 2026
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.
Rahman OF, et al. · Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026
Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance.
Mendias CL, et al. · Sports medicine (Auckland, N.Z.) · 2026
Synergy of GHK-Cu and hyaluronic acid on collagen IV upregulation via fibroblast and ex-vivo skin tests.
Jiang F, et al. · Journal of cosmetic dermatology · 2023
Glycyl-l-histidyl-l-lysine-Cu(2+) rescues cigarette smoking-induced skeletal muscle dysfunction via a sirtuin 1-dependent pathway.
Deng M, et al. · Journal of cachexia, sarcopenia and muscle · 2023
Results retrieved live from PubMed (NCBI). Research literature only — no medical advice.
Research peptides — Research Use Only
- Not for human consumption
- Not for the diagnosis, treatment or prevention of any disease
